Extracellular Matrix is an Important Component of Limbal Stem Cell Niche
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چکیده
منابع مشابه
Extracellular Matrix is an Important Component of Limbal Stem Cell Niche
Extracellular matrix plays an important role in stem cell niche which maintains the undifferentiated stem cell phenotype. Human corneal epithelial stem cells are presumed to reside mainly at the limbal basal epithelium. Efforts have been made to characterize different components of the extracellular matrix that are preferentially expressed at the limbus. Mounting evidence from experimental data...
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Yi Wen1,2, Sijun Hu3, Junjie Wu1,2* 1State Key Laboratory of Military Stomatology, Xi'an, Shaanxi Province, People's Republic of China 2Department of Orthodontics, Fourth Military Medical University, School of Stomatology, Xi'an, Shaanxi Province, People's Republic of China 3State Key Laboratory of Cancer Biology and Xijing Hospital of Digestive Diseases, The Fourth Military Medical University,...
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The intestinal epithelium comprises a monolayer of polarised columnar cells organised along the crypt-villus axis. Intestinal stem cells reside at the base of crypts and are constantly nourished by their surrounding niche for maintenance, self-renewal, and differentiation. The cellular microenvironment including the adjacent Paneth cells, stromal cells, smooth muscle cells, and neural cells as ...
متن کاملHyaluronan Rich Microenvironment in the Limbal Stem Cell Niche Regulates Limbal Stem Cell Differentiation
Purpose Limbal epithelial stem cells (LSCs), located in the basal layer of the corneal epithelium in the corneal limbus, are vital for maintaining the corneal epithelium. LSCs have a high capacity of self-renewal with increased potential for error-free proliferation and poor differentiation. To date, limited research has focused on unveiling the composition of the limbal stem cell niche, and, m...
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Although the existence of the limbal stem cell (LSC) niche is accepted, precise knowledge of its three-dimensional (3D) architecture remains incomplete. The LSC niche was explored on freshly excised and organ-cultured corneoscleral rims from human donors (n = 47), pigs (n = 15) and mice (n = 27) with full-field optical coherence microscopy (FFOCM). Limbal crypt features were detected in 90% of ...
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ژورنال
عنوان ژورنال: Journal of Functional Biomaterials
سال: 2012
ISSN: 2079-4983
DOI: 10.3390/jfb3040879